Target: NS3/4A Protease | Indication: Hepatitis C
Introduction / Brief Description
Danoprevir is a novel small-molecule inhibitor of the hepatitis C virus NS3/4A protease, jointly invented by Array and InterMune scientists. Roche acquired danoprevir from InterMune in 2010. InterMune has an obligation to make milestone payments to Array based on the selection and progress of danoprevir, as well as royalties on commercial sales of danoprevir. To date, Array has received $1.8 million in milestone payments and has the potential to earn an additional $7.5 million if all clinical and commercialization milestones for danoprevir are achieved under the agreement. Danoprevir is currently in Phase 3 clinical trials.
To learn more about danoprevir clinical trials, click here.
Danoprevir / Hepatitis C
Journal of Medicinal Chemistry
Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease